Covid Treatment Development
12-18-2021, 12:29 PM
#41
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Yes, it's not a single lock and key... more like velcro with various shaped hooks and loops, some of which mate up better than others. If you change some of the velcro, the rest might still work but not as strong.
12-18-2021, 12:34 PM
#42
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That's great news. Thanks for the clarification. I was under the impression that since they were using MONOclonal antibodies, it was just a single type of antibody that they found especially efficacious. Didn't realize they had used several.
Which brings me to what is probably a dumb question. I have heard that vaccines generate a polyclonal immune response.
So what's the difference between polyclonal antibodies and several different monoclonal antibodies?
12-18-2021, 12:42 PM
#43
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The difference is the source of production of the antibodies, they can be chemically identical to each other. Polyclonal would be antibodies produced from your many B-cells, where monoclonals are from a single cell, i.e. made in a lab.
12-18-2021, 12:44 PM
#44
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That's great news. Thanks for the clarification. I was under the impression that since they were using MONOclonal antibodies, it was just a single type of antibody that they found especially efficacious. Didn't realize they had used several.
Which brings me to what is probably a dumb question. I have heard that vaccines generate a polyclonal immune response.
So what's the difference between polyclonal antibodies and several different monoclonal antibodies?
Which brings me to what is probably a dumb question. I have heard that vaccines generate a polyclonal immune response.
So what's the difference between polyclonal antibodies and several different monoclonal antibodies?
An MCA cocktail is really an artificial attempt to provide a polyclonal-like response.
Mesabah can probably explain it better.
12-18-2021, 12:56 PM
#45
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Thanks fellas. Appreciate the explanation.
12-18-2021, 08:36 PM
#46
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It's better to think in terms of half lives. The half life of Covid antibodies is 10 weeks. With the original strain you got 5 half lives out of the vaccine, with Delta, it was 2.5 lives, with Omicron it's a about 1 half life. The booster schedule is likely to be 3 months between shots, that is what several countries are going with. Updating the vaccine does nothing without uping the dosage, in other words, you won't get more half lives from a new vaccine.
12-19-2021, 08:57 AM
#48
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Quarterly vaccinations would be required to prevent the spread, if you want to stay out of the hospital, you only need to take the vaccine once. The vaccine doesn't work by providing protective immunity, rather it tampers the IL-6 over response of the immune system that causes ARDS, blood clots, etc. This same treatment can be generated using mAbs CR3022, with cetirizine, with the onset of symptoms.
12-19-2021, 10:07 AM
#49
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Quarterly vaccinations would be required to prevent the spread, if you want to stay out of the hospital, you only need to take the vaccine once. The vaccine doesn't work by providing protective immunity, rather it tampers the IL-6 over response of the immune system that causes ARDS, blood clots, etc. This same treatment can be generated using mAbs CR3022, with cetirizine, with the onset of symptoms.
They've been tinkering around since 2006 with this. Apparently CR3014 and CR3022 combined could be quite effective. Not sure what happened to that avenue.
https://pubmed.ncbi.nlm.nih.gov/16796401/
12-23-2021, 08:51 AM
#50
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https://www.fda.gov/news-events/pres...tment-covid-19
Looks like we have a valid treatment now.
Sent from my BTV-W09 using Tapatalk
Looks like we have a valid treatment now.
Sent from my BTV-W09 using Tapatalk
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